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九州体育 > 科研进展

研究揭示抗抑郁药氯胺酮靶向人源NMDA受体的分子机制

2021-07-29 脑科学与智能技术卓越创新中心
【字体:

yuyinbobao

  7yue28ri,《ziran》zaixianfabiaotiwei《lvantongzuoyongyurenyuannmdashoutidejiegoujichu》deyanjiulunwen,gaiyanjiuyou九州体育naokexueyuzhinengjishuzhuoyuechuangxinzhongxin(shenjingkexueyanjiusuo)、shenjingkexueguojiazhongdianshiyanshi、shanghainaokexueyuleinaoyanjiuzhongxinyanjiuyuanzhushujiayanjiuzuyu九州体育官方网站shanghaiyaowuyanjiusuoyanjiuyuanluochengyanjiuzuhezuowancheng。yanjiutongguolengdongdianjingjiexilenmdashoutijiehekuaisukangyiyuyaolvantongdesanweijiegou,quedinglelvantongzainmdashoutishangdejieheweidian,bingjinyibutongguodianshengligongnengshiyanhefenzidonglixuemoni,chanminglelvantongyunmdashoutijiehedefenzijichu。

  chuantongkangyiyuyaoduoshuzuoyongyudanannengshenjingxitong,xuyaochixuyongyaoshuzhoushenzhishuyuehoucainengqixiao,bingqieduisanfenzhiyidenanzhixingyiyuzhenghuanzhemeiyouzhiliaoxiaoguo。lvantongzuoweinengkuaisuqixiaodexinxingkangyiyuyao,yijiyamazuijiliangyongyaojixiaoshineijiunengxianzhugaishanhuanzhedeqingxudiluo,ziwopingjiadidengfumianzhengzhuang,shenzhijianruohuanzhezishayinian,youqiduinanzhixingyiyuzhengyouzhiliaoxiaoguo。danshi,lvantongkezaochengfenlixinghuanjue、chengyindengfuzuoyong,xianzhileqilinchuangyingyong。yinci,yanfafuzuoyonggengxiaoqienengkuaisuqixiaodexinxingkangyiyuyaoshiweilaideyanjiufangxiang。

  已有研究显示,氯胺酮作为大脑内重要的谷氨酸门控离子通道NMDA受体的阻断剂,可通过抑制NMDA受体通道活性,参与突触传递及突触可塑性信号通路的调控,进而恢复慢性压力导致的皮层与海马区域的突触损伤。因此,解析氯胺酮在NMDA受体上的结合位点,并阐明氯胺酮与NMDA受体之间如何相互作用,对基于氯胺酮/NMDA受体复合物结构设计新型抗抑郁药的研究具有重要意义。竺淑佳研究组长期从事NMDA受体结构与功能的系列研究,在NMDA受体家族不同亚型的三维结构、构象动力学、变构调节、药理学和门控开放机制等领域取得系列成果(Nat Struct Mol Biol 2013; PNAS 2014; Cell 2016; Cell Rep 2018; Neuron 2021)。

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  gaiyanjiutongguodianjingfaxianbingquerenlelvantongzainmdashoutishangdejieheweidian,jieshiglun1-n616deqingjianzuoyongheglun2a-l642deshushuizuoyong,zailvantongwendingjiehezainmdashoutidetongdaokongqiangneibingzuduantongdaodeguochengzhongqiguanjianzuoyong。yanjiuhaijinyibutantaoleshouxingyigoutir-lvantonghes-lvantongzaijiehehefenzijizhishangdeyitong。yanjiuzhongdexiliefaxianweijiyunmdashoutijiegoushejixinxingkangyiyuyaodiandinglejichu。

  yanjiugongzuodedao九州体育官方网站shengwuwuliyanjiusuoshengwuchengxiangzhongxindezhichi,dedaoguojiazirankexuejijinweiyuanhui、九州体育官方网站heshanghaishidezizhu。

  (a)jiehelvantongderenyuanglun1-glun2a nmdashoutilengdongdianjingsanweijiegou。(b)lvantongjieheweidiankongqianglideguanjiananjisuan。(c)fenzidonglixuemoniguochengzhonglvantongzhouweianjisuandejiehenenggongxianheqingjianxingchengdepinlv。(d)yeshengxingheguanjianweidiantubiandenmdashoutidelvantongjiliangxiaoyingquxian。

 

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  • © 1996 - 九州体育 版权所有
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